https://plu.mx/plum/a/?doi=10.1016/j.mcna.2019.09.002
https://www.medical.theclinics.com/article/S0025-7125(19)30103-8/abstract
Medical Clinics, January 2020, Volume 104, Issue 1, Pages 177–187
Dilawar Khokhar, MD, Cem Akin, MD, PhD (Department of Internal Medicine, Division of Allergy and Clinical Immunology, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby H Suite H-2100, Ann Arbor, MI 48106, USA)
Mast cell activation syndrome (MCAS) is a heterogeneous and rare disorder with episodic and severe activation of mast cells. Because symptoms of mast cell activation are nonspecific, it is important to base the diagnosis on best available clinical and scientific evidence, and not make it one of exclusion. MCAS, much like the mast cell itself, as a whole is greater than the sum of its proposed diagnostic criteria. When each component is considered in isolation, criteria can seem nonspecific, and thus, a broad constellation of symptoms can be attributed to MCAS when they may be due to other disease processes.
Keywords: Mast cell activation, MCAS, Mast cell disorder, Mastocytosis, Idiopathic anaphylaxis, Tryptase, Mast cell mediators
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