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Concurrent mastocytosis and monoclonal gammopathy of undetermined significance, a case series

https://www.jacionline.org/article/S0091-6749(18)32293-0/abstract

The Journal of Allergy and Clinical Immunology, February 2019, Volume 143, Issue 2, Supplement, Page AB180

Annely Richardson, MD, Joseph H. Butterfield, MD FAAAAI (Mayo Clinic, Rochester, MN)

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Mast cells within cellular networks

https://www.sciencedirect.com/science/article/pii/S0091674919301885

Journal of Allergy and Clinical Immunology, Available online 5 February 2019

Michael Stassen PhD, Ann-Kathrin Hartmann MSc, Sharon Jiménez Delgado MSc, Susann Dehmel PhD, Armin Braun PhD

Abstract

Mast cells are highly versatile in terms of their mode of activation by a host of stimuli and their ability to flexibly release a plethora of biologically highly active mediators. Within the immune system, mast cells can best be designated as an active nexus interlinking innate and adaptive immunity. Herein, we try to draw an arc from the initiation of acute inflammatory reactions to microbial pathogens to the development of adaptive immunity and allergies. This multifaceted nature of mast cells is made possible by the interaction with multiple cell types of immunological and non-immunological origin. Examples for the former include neutrophils, eosinophils, T cells and professional antigen presenting cells. These interactions allow mast cells to orchestrate inflammatory innate reactions and complex adaptive immunity, including the pathogenesis of allergies.

Important partners of non-immunological origin include cells of the sensory neuronal system. The intimate association between mast cells and sensory nerve fibers allows bidirectional communication leading to neurogenic inflammation. Evidence is accumulating that this mast cell / nerve crosstalk is of pathophysiological relevance in allergic diseases like asthma.

Key words

Mast cells neutrophils eosinophils T cells asthma mCMV infection vaccination substance P sensory nerves neurogenic inflammation

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Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin

https://www.mdpi.com/2076-3921/8/2/35/pdf

Antioxidants, Published: 5 February 2019

Rashida Ginwala, Raina Bhavsar, De Gaulle I. Chigbu, Pooja Jain and Zafar K. Khan

Department of Microbiology and Immunology, and Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA

Abstract: Inflammation has been reported to be intimately linked to the development or worsening of several non-infectious diseases. A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. For centuries, flavonoids and their preparations have been used to treat various human illnesses, and their continual use has persevered throughout the ages. This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics. Additionally, inflammation in the central nervous system (CNS) due to diseases such as multiple sclerosis (MS) gives ready access to circulating lymphocytes, monocytes/macrophages, and dendritic cells (DCs), causing edema, further inflammation, and demyelination. As the dearth of safe anti-inflammatory therapies is dire in the case of CNS-related disorders, we reviewed the neuroprotective actions of apigenin and other flavonoids. Existing epidemiological and pre-clinical studies present considerable evidence in favor of developing apigenin as a natural alternative therapy against chronic inflammatory conditions.

Keywords: natural products; flavonoids; apigenin; dendritic cells; neuroinflammation; chronic inflammation

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Characterization and Comparison of Human LAD1 Mast Cells with Human LAD2 Mast Cells

https://www.jacionline.org/article/S0091-6749(18)32292-9/abstract

The Journal of Allergy and Clinical Immunology, February 2019, Volume 143, Issue 2, Supplement, Page AB180

Arnold S. Kirshenbaum, MD FAAAAI, Yuzhi Yin, PhD, J.B. Sundstrom, PhD, Geethani Bandara, PhD, Dean D. Metcalfe, MD, FAAAAI

LAD2 human mast cells were developed over 15 years ago and have been distributed worldwide for studying proliferation, receptor expression, mediator release/inhibition and signaling. LAD2 cells were derived from CD34+ cells following marrow aspiration of a patient with aggressive mastocytosis. Another aspiration gave rise to the cell line LAD1 which has been under liquid N2 and not distributed due to the availability of LAD2. LAD1 cells were recently thawed for study. We queried whether LAD1 had unique properties for the study of human mast cell biology

© 2018 Published by Elsevier Inc.

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Stimulation of LUVA Mast Cells by Beta-casomorphin 7 and Gliadorphin

https://www.jacionline.org/article/S0091-6749(18)32296-6/abstract

The Journal of Allergy and Clinical Immunology, February 2019, Volume 143, Issue 2, Supplement, Page AB181

Julia K. Sohn, MD, John W. Steinke, PhD FAAAAI, Larry Borish, MD FAAAAI, Emily C. McGowan, MD, PhD

Abstract

Milk and wheat have been implicated in numerous non-IgE mediated diseases, including eosinophilic esophagitis, gastrointestinal intolerance, and autism spectrum disorder, but the underlying mechanism is unknown. Beta-casomorphin 7 (BCM7) is an opioid receptor agonist peptide generated from milk of “A1” cattle, and gliadorphin (G7) is the gluten homologue. While BCM-7 has been shown to stimulate rat peritoneal mast cells, this has not been reported in humans, nor with G7.

© 2018 Published by Elsevier Inc.

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Are outcome measures in allergic diseases relevant for the WHO’s International Classification of Diseases in allergology?

https://journals.lww.com/co-allergy/Abstract/publishahead/Are_outcome_measures_in_allergic_diseases_relevant.99180.aspx

Tanno, Luciana Kase; Demoly, Pascal on behalf of the Joint Allergy Academies

Current Opinion in Allergy and Clinical Immunology: February 5, 2019 – Volume Publish Ahead of Print – Issue – p. doi: 10.1097/ACI.0000000000000524

Abstract

Purpose of review To review and understand the impact of the outcome measures of allergic and hypersensitivity conditions for the WHO’s International Classification of Diseases (ICD) and its impact in the management of anaphylaxis and identify potential strategies to improve patients’ care and prevention.

Recent findings The pioneer chapter addressed to allergic and hypersensitivity conditions in the 11th version of the WHO’s ICD is the result of the evidence-based academic technical actions consistently following of collaborations of the allergy community and integrated international initiatives in order to reach quality outcomes measures of allergies worldwide.

Summary Allergic and hypersensitivity conditions are increasing worldwide, however, they have never been well represented in the international classification systems, such as the ICD. The ALLERGY in ICD-11 initiative has been launched in 2012 in order to gather a better representation of these conditions in the ICD-11. As a result of the evidence-based academic technical actions acknowledged by the Joint Allergy Academies and the WHO, the pioneer chapter Allergy and hypersensitivity conditions has been constructed. This framework can be considered a milestone in the history of the allergy specialty. More reliable, accurate and comparable epidemiological data will be able to provide a big picture of these conditions and will support improvements in many levels of the health system. As knowledge derived from populations is key information for more realistic decision-making, the construction of the new section addressed to allergic and hypersensitivity conditions in the ICD-11 will allow the collection of more accurate epidemiological data to support quality management of patients, and better facilitate healthcare planning to implement public health measures to prevent and reduce the morbidity and mortality attributable to these conditions.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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Drug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach

https://www.jidonline.org/article/S0022-202X(18)32680-0/fulltext

Journal of Investigative Dermatology, March 2019Volume 139, Issue 3, Pages 683–691

Matthew T. Patrick, Kalpana Raja, Keylonnie Miller, Jason Sotzen, Johann E. Gudjonsson, James T. Elder, Lam C. Tsoi

Immune-mediated diseases affect more than 20% of the population, and many autoimmune diseases affect the skin. Drug repurposing (or repositioning) is a cost-effective approach for finding drugs that can be used to treat diseases for which they are currently not prescribed. We implemented an efficient bioinformatics approach using word embedding to summarize drug information from more than 20 million articles and applied machine learning to model the drug-disease relationship. We trained our drug repurposing approach separately on nine cutaneous diseases (including psoriasis, atopic dermatitis, and alopecia areata) and eight other immune-mediated diseases and obtained a mean area under the receiver operating characteristic of 0.93 in cross-validation. Focusing in particular on psoriasis, a chronic inflammatory condition of skin that affects more than 100 million people worldwide, we were able to confirm drugs that are known to be effective for psoriasis and to identify potential candidates used to treat other diseases. Furthermore, the targets of drug candidates predicted by our approach were significantly enriched among genes differentially expressed in psoriatic lesional skin from a large-scale RNA sequencing cohort. Although our algorithm cannot be used to determine clinical efficacy, our work provides an approach for suggesting drugs for repurposing to immune-mediated cutaneous diseases.

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