https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403285/abstract
Front. Pharmacol. / Sec. Ethnopharmacology / Volume 15 – 2024 | doi: 10.3389/fphar.2024.1403285. Accepted: 29 Apr 2024.
Jung-Mi Oh, HyunHo Yoon, Jae-Yeol Joo, Wan-Taek Im, Sungkun Chun
Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential as a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, and age-related diseases. This study assessed the impact of ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation and atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness and lymph node nodules and suppressed the expression and secretion of histamine and pro-inflammatory cytokines. It also significantly lowered the production of inflammatory response mediators including ROS, leukotriene C4 (LTC4), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). GLE inhibited the phosphorylation of MAPKs (ERK, P38, JNK) and the activation of NF-κB, which are both linked to inflammatory cytokine expression. We demonstrated that GLE’s inhibitory effect on mast cell-mediated allergic inflammation is due to the blockade of the NF-κB and inflammasome pathways. Our findings suggest that GLE can be an effective therapeutic agent for mast-cell mediated and allergic inflammatory conditions.
Keywords: GLE, ginseng leaf extract, AD, atopic dermatitis, BSA, bovine serum albumin, COX, cyclooxygenase, DMEM, Dulbecco’s modified Eagle’s medium, DMSO, dimethyl sulfoxide, DNCB, 2,4-dinitrochlorobenzene, ELISA, enzyme-linked immunosorbent assay
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