https://www.jaci-global.org/article/S2772-8293(24)00086-9/fulltext
JACI Global, Published: June 11, 2024. DOI: https://doi.org/10.1016/j.jacig.2024.100290
Hugo WF. Mak, MBBS, Elaine Lee, MSc, Jane CY. Wong, MBBS, Karsten Weller, MD, Marcus Maurer, MD, Philip H. Li, MD
Abstract
Background
Uncontrolled chronic urticaria (CU) can severely impact physical and psychosocial health, as well as quality of life. Patient reported outcome measures are crucial for measuring disease control. The Urticaria Control Test (UCT) is recommended by guidelines to monitor CU and guide clinical management. However, the traditional Chinese version of the UCT has not yet been validated.
Objective
To validate the traditional Chinese UCT among Chinese CU patients in Hong Kong.
Methods
Patients with CU were enrolled at a Urticaria Centre of Reference and Excellence (UCARE) in Hong Kong and completed the traditional Chinese UCT. The internal consistency, test-retest reliability, construct validity, convergent validity, known-group validity and sensitivity to change of the traditional Chinese UCT were evaluated.
Results
We recruited 162 CU patients (80.9% female; 50±14 years) with mean(median) baseline UCT score of 8.8(8)±4.7. Overall, Chinese UCT showed excellent internal consistency (Cronbach’s α and McDonald’s ω: 0.948), as well as test-retest reliability (intraclass correlation coefficient=0.916 [95% confidence interval=0.866–0.953]). Exploratory factor analysis revealed a unidimensional structure and confirmed its construct validity. Strong correlation between UCT and the weekly Urticaria Activity Score (UAS7) attested its convergent validity (ρ=-0.699, p<0.001). Its known-group validity was supported by significantly different UCT scores among patient subgroups with different disease activity. The Chinese UCT also demonstrated good sensitivity to change, as reflected by the significant correlation between changes in UCT and UAS7 scores (ρ=0.491, p<0.001).
Conclusion
The traditional Chinese UCT is a valid, reliable, and sensitive to change instrument among Hong Kong Chinese with CU.
Keywords: Chinese chronic control patient-reported outcome measures spontaneous urticaria validation
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