Mast cells: The Janus of type 2 inflammation

Posted on June 17, 2024 by mastopedia

https://www.cell.com/immunity/abstract/S1074-7613(24)00265-6

Immunity, Volume 57, ISSUE 6, P1182-1184, June 11, 2024. DOI: https://doi.org/10.1016/j.immuni.2024.05.011

Johanna Kotrba, Anne Dudeck

Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.

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