https://www.clausiuspress.com/assets/default/article/2024/05/13/article_1715614416.pdf
MEDS Chinese Medicine (2024) Clausius Scientific Press, Canada. DOI: 10.23977/medcm.2024.060206
Ma Chao, Zhi Liqin (Shaanxi University of Chinese Medicine, Xianyang, 712046, China; Affiliated Hospital of Integrated Traditional and Western Medicine of Shaanxi University of Chinese Medicine, Xi’an, 710000, China)
Abstract: The formation of cardiac hypertrophy is an important pathological change leading to chronic heart failure, which determines the development and prognosis of CHF. When the heart is damaged and stressed, the cardiomyocytes become hypertrophic and lead to changes in cellular metabolic patterns, which ultimately affect the structure and function of the heart. Qijia Wuling soup is the experience prescription of treating heart failure by the chief physician of Staff Liqin. In this study, we found that it could improve the echocardiographic parameters and relieve the symptoms of CHF in rats. In this study, the effect and mechanism of Qijia Wuling soup on myocardial hypertrophy in rats with CHF were investigated on the basis of the previous studies which proved that Qijia Wuling soup was effective in the treatment of CHF, to provide evidence for improving cardiac hypertrophy. H9C2 cells were inoculated into 6-well plate and randomly divided into control group and model group. Study it. This study demonstrated that qjwlt-containing serum had a significant protective effect on H9C2 cardiomyocytes injury induced by (-)-noradrenaline. This provides an important experimental and theoretical basis for the clinical application of qjwlt in the treatment of heart failure and improvement of cardiac hypertrophy. With the in-depth study of its mechanism of action, Qijia Wuling soup is expected to become one of the effective drugs in the treatment of CHF, bringing better therapeutic effect and quality of life for patients.
Keywords: Qijia Wuling soup; CHF; cardiac hypertrophy; BNP; ANP; AKT1
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