http://content.karger.com/ProdukteDB/produkte.asp?Doi=321614 (excerpts follow)
Int Arch Allergy Immunol. 2011;155(4):355-60, Metz M, Doyle E, Bindslev-Jensen C, Watanabe T, Zuberbier T, Maurer M, Dept of Dermatology and Allergy, Allergie-Centrum-Charit??, Charit?? – Universit??tsmedizin Berlin, Germany
Sedating and non-sedating histamine H(1) receptor (H1R) antagonists and H2R blockers are widely used drugs which are generally considered to be safe medications. However, recently, these drugs have been shown to possibly impair the outcome of perforating appendicitis in children.
oral treatment with first-generation H1R antihistamine diphenhydramine, H2R blocker cimetidine and H3/4R blocker thioperamide impairs optimal innate immune responses in severe murine bacterial sepsis.
the second-generation antihistamine desloratadine neither affects morbidity nor mortality after CLP.
sedating first-generation H1R antihistamines and H2R blockers might impair innate immune responses to bacteria and that these drugs should be used with caution in patients with severe bacterial infections.
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