Anaphylaxis pathogenesis and treatment

http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02629.x/abstract (excerpts follow)

Allergy. 2011 Jul;66 Suppl 95:31-4, Simons FE, U of Manitoba, Winnipeg, Canada

Diagnosis of anaphylaxis is currently based on established clinical criteria.

Epinephrine (adrenaline) is the first-line medication for anaphylaxis treatment and delay in injecting it contributes to biphasic reactions, hypoxic-ischemic encephalopathy, and fatality.